"Which of the following residues if replaced with a neutral leucine residue would cause the protein to become the most stable?
a) D12
b) D48
c) E6
d) E47
Explanation: The passage states that the change in pKa closely reflects the change in G between the unfolded and unfolded protein states. Therefore, the residue with the largest change in pKa in the positive direction will destabilize the protein the most."
Graph is attached. I got this question correct just based on "one of...
EK FL 1: pKa and Protein Stability
a) D12
b) D48
c) E6
d) E47
Explanation: The passage states that the change in pKa closely reflects the change in G between the unfolded and unfolded protein states. Therefore, the residue with the largest change in pKa in the positive direction will destabilize the protein the most."
Graph is attached. I got this question correct just based on "one of...
EK FL 1: pKa and Protein Stability