"ATP bound to the substrate site activates the reduction of pyrimidines (CDP and UDP) to form deoxycytidine diphosphate (dCDP) and deoxyuridine diphosphate (dUDP). The dUDP is not used for DNA synthesis; rather, it is used to produce deoxythymidine monophosphate (dTMP). Once dTMP is produced, it is phosphorylated to dTTP, which then binds to the substrate site and induces the reduction of GDP. As dGTP accumulates, it replaces dTTP in...
Regulation of ribonucleotide reductase
Regulation of ribonucleotide reductase