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Can someone please explain the differences in protein domains

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AAMC Bio/biochem Section Bank Q#63 asks which protein domain of STAT3 is NOT predicted to play a role in it's signaling?
A. Nuclear localization domain
B. Signal sequence domain
C. DNA binding domain
D. Protein binding domain

The correct answer is B, but I unfortunately can't recall the functions of the other domains. Can someone please explain the differences between them? Thank you!

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