Phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) phosphorylates phosphatidylinositol (4,5)-bisphosphate (or PIP2) to generate the second messenger phosphatidylinositol (3,4,5)-trisphosphate (PIP3). The morpholine-containing chemical LY294002 is cell permeable and is a competitive inhibitor of ATP binding PI3K. Each of the following is true EXCEPT:
A. LY294002 can simply diffuse into the cell across the plasma membrane, and increases the Km for the PI3K phosphorylation reaction.
B....
Does enzyme inhibitor change ΔG?
A. LY294002 can simply diffuse into the cell across the plasma membrane, and increases the Km for the PI3K phosphorylation reaction.
B....
Does enzyme inhibitor change ΔG?